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The physiological relevance of the kinetic uncoupling is that it allows the formation of stable complexes, for example, with ironsulfur clusters or disulfide-bonded interaction partners

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The immunoinhibitory capability of PERK-ablated MDSCs was restored by blocking Type-I interferon receptor-I, conditionally via deleting STING or reactivating NRF2 signaling

PSAT1 is also involved in the serine synthesis pathway, which is essential for many breast cancers [119]